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阿比特龍|abiraterone

阿比特龍|abiraterone 用法劑量

阿(a)比(bi)(bi)特(te)(te)(te)龍推薦劑量：阿(a)比(bi)(bi)特(te)(te)(te)龍是口服(fu)給(gei)予1,000 mg阿(a)比(bi)(bi)特(te)(te)(te)龍每(mei)天1次與潑尼松5 mg口服(fu)給(gei)藥每(mei)天2次聯用。阿(a)比(bi)(bi)特(te)(te)(te)龍必須空(kong)胃給(gei)藥。服(fu)用阿(a)比(bi)(bi)特(te)(te)(te)龍前至(zhi)少(shao)2小時(shi)和服(fu)用阿(a)比(bi)(bi)特(te)(te)(te)龍后至(zhi)少(shao)1小時(shi)不應消耗(hao)食物[阿(a)比(bi)(bi)特(te)(te)(te)龍見臨床藥理(li)學]。阿(a)比(bi)(bi)特(te)(te)(te)龍應與水吞服(fu)整片。
阿比(bi)特龍肝受損阿比(bi)特龍劑量(liang)調整(zheng)指(zhi)導
有(you)基(ji)線中(zhong)(zhong)(zhong)(zhong)度肝受損(sun)(sun)(Child-Pugh類別B)患者(zhe)(zhe)中(zhong)(zhong)(zhong)(zhong)減(jian)(jian)低推(tui)薦阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)劑(ji)量(liang)：阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)減(jian)(jian)至250 mg阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)每(mei)天(tian)(tian)1次(ci)(ci)阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)。每(mei)天(tian)(tian)1次(ci)(ci)阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)劑(ji)量(liang)250 mg 阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)在(zai)(zai)(zai)有(you)中(zhong)(zhong)(zhong)(zhong)度肝受損(sun)(sun)患者(zhe)(zhe)中(zhong)(zhong)(zhong)(zhong)預計導致(zhi)曲線下(xia)面(mian)積(AUC)與正常肝功(gong)能接受阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)1,000 mg每(mei)天(tian)(tian)1次(ci)(ci)阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)所見AUC相(xiang)似。但是，在(zai)(zai)(zai)有(you)中(zhong)(zhong)(zhong)(zhong)度肝受損(sun)(sun)患者(zhe)(zhe)中(zhong)(zhong)(zhong)(zhong)阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)劑(ji)量(liang)250 mg阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)每(mei)天(tian)(tian)1次(ci)(ci)阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)，阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)沒(mei)有(you)臨(lin)床(chuang)(chuang)資料和建議小心。在(zai)(zai)(zai)有(you)中(zhong)(zhong)(zhong)(zhong)度肝受損(sun)(sun)患者(zhe)(zhe)中(zhong)(zhong)(zhong)(zhong)開始阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)治療(liao)前，頭一(yi)個月(yue)每(mei)周(zhou)，阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)治療(liao)的(de)兩個月(yue)后每(mei)2周(zhou)和其后每(mei)月(yue)監視(shi)ALT，AST，和膽紅素。如果在(zai)(zai)(zai)有(you)基(ji)線嚴(yan)重(zhong)肝受損(sun)(sun)患者(zhe)(zhe)中(zhong)(zhong)(zhong)(zhong)發(fa)生ALT和/或AST的(de)升高(gao)大于5 × 正常上限(ULN)或總膽紅素大于3 × ULN，終止(zhi)阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)和不(bu)要再(zai)次(ci)(ci)用(yong)阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)治療(liao)患者(zhe)(zhe)[見阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)特(te)殊人群中(zhong)(zhong)(zhong)(zhong)阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)使用(yong)和阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)臨(lin)床(chuang)(chuang)藥理學]。在(zai)(zai)(zai)有(you)基(ji)線嚴(yan)重(zhong)肝受損(sun)(sun)(Child-Pugh類別C)患者(zhe)(zhe)中(zhong)(zhong)(zhong)(zhong)避免用(yong)阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)，因為尚未曾在(zai)(zai)(zai)此(ci)人群中(zhong)(zhong)(zhong)(zhong)研究(jiu)阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)，和不(bu)可能預測阿(a)(a)(a)(a)(a)比(bi)(bi)(bi)(bi)(bi)(bi)(bi)(bi)特(te)龍(long)劑(ji)量(liang)調整。
阿比(bi)特龍肝(gan)毒性
阿(a)比(bi)(bi)特龍(long)(long)(long)對治療(liao)用(yong)阿(a)比(bi)(bi)特龍(long)(long)(long)期間發生肝毒性患(huan)者(ALT和(he)/或AST大于(yu)(yu)5 × ULN或總(zong)膽紅(hong)素(su)大于(yu)(yu)3 × ULN)，中(zhong)斷(duan)ZYTIGA治療(liao)[見(jian)阿(a)比(bi)(bi)特龍(long)(long)(long)警(jing)告和(he)阿(a)比(bi)(bi)特龍(long)(long)(long)注意(yi)事項]。阿(a)比(bi)(bi)特龍(long)(long)(long)在肝功能檢驗返回患(huan)者的基線或AST和(he)ALT低于(yu)(yu)或等于(yu)(yu)2.5 × ULN和(he)總(zong)膽紅(hong)素(su)低于(yu)(yu)或等于(yu)(yu)1.5 × ULN后可減低劑量至750 mg每天1次再次阿(a)比(bi)(bi)特龍(long)(long)(long)治療(liao)。阿(a)比(bi)(bi)特龍(long)(long)(long)對恢復阿(a)比(bi)(bi)特龍(long)(long)(long)治療(liao)患(huan)者，監視血(xue)清轉氨酶(mei)和(he)膽紅(hong)素(su)對三個月(yue)(yue)最(zui)少每2周1次和(he)其(qi)后每月(yue)(yue)1次。
如(ru)果在(zai)阿(a)比(bi)(bi)(bi)特(te)(te)龍(long)劑量750 mg阿(a)比(bi)(bi)(bi)特(te)(te)龍(long)每(mei)天(tian)1次阿(a)比(bi)(bi)(bi)特(te)(te)龍(long)肝(gan)毒性復(fu)發，在(zai)在(zai)肝(gan)功能(neng)檢驗返回至患者的基線或(huo)至AST和ALT低于(yu)(yu)或(huo)等于(yu)(yu)2.5 × ULN和總膽紅素低于(yu)(yu)或(huo)等于(yu)(yu)1.5 × ULN后可在(zai)減低阿(a)比(bi)(bi)(bi)特(te)(te)龍(long)劑量500 mg阿(a)比(bi)(bi)(bi)特(te)(te)龍(long)每(mei)天(tian)1次阿(a)比(bi)(bi)(bi)特(te)(te)龍(long)再(zai)次開始(shi)阿(a)比(bi)(bi)(bi)特(te)(te)龍(long)治療。
如果低阿(a)比特(te)龍(long)(long)劑量500 mg阿(a)比特(te)龍(long)(long)每天1次阿(a)比特(te)龍(long)(long)時肝毒性復(fu)發(fa)。終止用阿(a)比特(te)龍(long)(long)治療(liao)。患者發(fa)生AST或(huo)ALT大(da)于(yu)或(huo)等(deng)于(yu)20 × ULN和(he)/或(huo)膽紅(hong)素大(da)于(yu)或(huo)等(deng)于(yu)10 × ULN時，ZYTIGA再次阿(a)比特(te)龍(long)(long)治療(liao)的(de)安(an)全性不知道。

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