適(shi)應(ying)(ying)癥(zheng)(zheng)： 接受克唑替尼（crizotinib）治(zhi)(zhi)療(liao)(liao)后(hou)出現(xian)疾(ji)病進(jin)展或(huo)(huo)(huo)(huo)對(dui)克唑替尼（crizotinib）不耐受的(de)(de)(de)ALK陽性(xing)轉移性(xing)非小細(xi)胞肺(fei)(fei)癌（NSCLC）患(huan)(huan)(huan)者(zhe)(zhe)。FDA根據臨(lin)(lin)(lin)床(chuang)試驗的(de)(de)(de)腫(zhong)瘤(liu)緩(huan)解(jie)(jie)(jie)率和(he)緩(huan)解(jie)(jie)(jie)持續(xu)時間(jian)(jian)數據加速批(pi)準(zhun)(zhun)ZYKADIA用(yong)于(yu)(yu)治(zhi)(zhi)療(liao)(liao)上述適(shi)應(ying)(ying)癥(zheng)(zheng)。生(sheng)存期(qi)(qi)(qi)或(huo)(huo)(huo)(huo)疾(ji)病相(xiang)關癥(zheng)(zheng)狀的(de)(de)(de)改善情況尚未(wei)確定。對(dui)ZYKADIA用(yong)于(yu)(yu)治(zhi)(zhi)療(liao)(liao)該(gai)(gai)適(shi)應(ying)(ying)癥(zheng)(zheng)的(de)(de)(de)進(jin)一步批(pi)準(zhun)(zhun)可(ke)(ke)(ke)能取(qu)決于(yu)(yu)驗證性(xing)試驗對(dui)臨(lin)(lin)(lin)床(chuang)獲益(yi)的(de)(de)(de)驗證與(yu)描述。 不良(liang)反應(ying)(ying)： 惡心,嘔吐(tu)(tu),腹(fu)(fu)(fu)瀉(xie)(xie),轉氨(an)酶升高,便秘,食欲減退,腹(fu)(fu)(fu)痛,疲勞 用(yong)法用(yong)量： 750 mg 口服(fu)，每天1次，空腹(fu)(fu)(fu)服(fu)用(yong)（即：勿(wu)在(zai)飯后(hou)2小時內服(fu)用(yong)） 注意(yi)事項(xiang)： 嚴重(zhong)或(huo)(huo)(huo)(huo)持續(xu)性(xing)的(de)(de)(de)胃腸道毒(du)(du)(du)性(xing)反應(ying)(ying)：臨(lin)(lin)(lin)床(chuang)試驗中(zhong)(zhong)(zhong)，38%的(de)(de)(de)患(huan)(huan)(huan)者(zhe)(zhe)因出現(xian)腹(fu)(fu)(fu)瀉(xie)(xie)、惡心嘔吐(tu)(tu)或(huo)(huo)(huo)(huo)腹(fu)(fu)(fu)痛而調整用(yong)藥(yao)(yao)(yao)(yao)(yao)(yao)劑(ji)(ji)(ji)量。如止吐(tu)(tu)藥(yao)(yao)(yao)(yao)(yao)(yao)或(huo)(huo)(huo)(huo)止瀉(xie)(xie)藥(yao)(yao)(yao)(yao)(yao)(yao)無效(xiao)，則應(ying)(ying)減少(shao)ZYKADIA劑(ji)(ji)(ji)量。 肝(gan)中(zhong)(zhong)(zhong)毒(du)(du)(du)：ZYKADIA可(ke)(ke)(ke)引起(qi)肝(gan)中(zhong)(zhong)(zhong)毒(du)(du)(du)。至少(shao)每月做(zuo)一次肝(gan)臟(zang)實驗室檢查。如果出現(xian)異常則暫停(ting)(ting)(ting)給(gei)藥(yao)(yao)(yao)(yao)(yao)(yao)，之后(hou)減少(shao)劑(ji)(ji)(ji)量，或(huo)(huo)(huo)(huo)永(yong)(yong)久(jiu)停(ting)(ting)(ting)藥(yao)(yao)(yao)(yao)(yao)(yao)。 間(jian)(jian)質性(xing)肺(fei)(fei)病（ILD）/肺(fei)(fei)炎：臨(lin)(lin)(lin)床(chuang)試驗中(zhong)(zhong)(zhong)，有(you)(you)4%的(de)(de)(de)患(huan)(huan)(huan)者(zhe)(zhe)出現(xian)間(jian)(jian)質性(xing)肺(fei)(fei)病（ILD）/肺(fei)(fei)炎。如確診患(huan)(huan)(huan)者(zhe)(zhe)出現(xian)與(yu)ZYKADIA治(zhi)(zhi)療(liao)(liao)有(you)(you)關的(de)(de)(de)ILD/肺(fei)(fei)炎，應(ying)(ying)永(yong)(yong)久(jiu)停(ting)(ting)(ting)藥(yao)(yao)(yao)(yao)(yao)(yao)。 QT間(jian)(jian)期(qi)(qi)(qi)延長: ZYKADIA可(ke)(ke)(ke)導(dao)致QTc間(jian)(jian)期(qi)(qi)(qi)延長。對(dui)于(yu)(yu)充(chong)血(xue)性(xing)心力衰竭、心動過緩(huan)、電(dian)解(jie)(jie)(jie)質異常患(huan)(huan)(huan)者(zhe)(zhe)，或(huo)(huo)(huo)(huo)正在(zai)服(fu)用(yong)可(ke)(ke)(ke)導(dao)致QTc間(jian)(jian)期(qi)(qi)(qi)延長藥(yao)(yao)(yao)(yao)(yao)(yao)物的(de)(de)(de)患(huan)(huan)(huan)者(zhe)(zhe)，應(ying)(ying)監測(ce)其心電(dian)圖和(he)電(dian)解(jie)(jie)(jie)質。暫停(ting)(ting)(ting)給(gei)藥(yao)(yao)(yao)(yao)(yao)(yao)，之后(hou)減少(shao)劑(ji)(ji)(ji)量，或(huo)(huo)(huo)(huo)永(yong)(yong)久(jiu)停(ting)(ting)(ting)藥(yao)(yao)(yao)(yao)(yao)(yao)。 高血(xue)糖(tang)(tang)(tang)：ZYKADIA可(ke)(ke)(ke)導(dao)致高血(xue)糖(tang)(tang)(tang)。應(ying)(ying)在(zai)治(zhi)(zhi)療(liao)(liao)前監測(ce)空腹(fu)(fu)(fu)血(xue)糖(tang)(tang)(tang)，如果有(you)(you)臨(lin)(lin)(lin)床(chuang)需要，隨(sui)后(hou)應(ying)(ying)定期(qi)(qi)(qi)監測(ce)。如果出現(xian)臨(lin)(lin)(lin)床(chuang)表現(xian)，應(ying)(ying)開始服(fu)用(yong)或(huo)(huo)(huo)(huo)優(you)化降血(xue)糖(tang)(tang)(tang)藥(yao)(yao)(yao)(yao)(yao)(yao)物。暫停(ting)(ting)(ting)給(gei)藥(yao)(yao)(yao)(yao)(yao)(yao)，之后(hou)減少(shao)劑(ji)(ji)(ji)量，或(huo)(huo)(huo)(huo)永(yong)(yong)久(jiu)停(ting)(ting)(ting)藥(yao)(yao)(yao)(yao)(yao)(yao)。心動過緩(huan)：ZYKADIA可(ke)(ke)(ke)導(dao)致心動過緩(huan)。定期(qi)(qi)(qi)監測(ce)心跳及(ji)血(xue)壓。暫停(ting)(ting)(ting)給(gei)藥(yao)(yao)(yao)(yao)(yao)(yao)，之后(hou)減少(shao)劑(ji)(ji)(ji)量，或(huo)(huo)(huo)(huo)永(yong)(yong)久(jiu)停(ting)(ting)(ting)藥(yao)(yao)(yao)(yao)(yao)(yao)。 胰(yi)腺(xian)炎：患(huan)(huan)(huan)者(zhe)(zhe)可(ke)(ke)(ke)能會出現(xian)脂肪酶和(he)/或(huo)(huo)(huo)(huo)淀(dian)粉(fen)酶升高以及(ji)胰(yi)腺(xian)炎。治(zhi)(zhi)療(liao)(liao)前監測(ce)脂肪酶和(he)淀(dian)粉(fen)酶，如果有(you)(you)臨(lin)(lin)(lin)床(chuang)需要，隨(sui)后(hou)應(ying)(ying)定期(qi)(qi)(qi)監測(ce)。 胚胎-胎兒毒(du)(du)(du)性(xing)：ZYKADIA可(ke)(ke)(ke)對(dui)胎兒造成傷害。請(qing)告(gao)知有(you)(you)生(sheng)育(yu)能力的(de)(de)(de)女性(xing)患(huan)(huan)(huan)者(zhe)(zhe)，該(gai)(gai)藥(yao)(yao)(yao)(yao)(yao)(yao)對(dui)胎兒有(you)(you)潛在(zai)風險。